PK-THPP, CAS 1332454-07-5

Formulation: A crystalline solid

Formal Name: 1-[1-[6-([1,1′-biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone

Purity: ≥98%

Formula Markup: C29H32N4O2

Formula Weight: 468,6

Shelf life (days): 1460

CAS Number: 1332454-07-5

Notes: PK-THPP is a brain-penetrant inhibitor of the two-pore domain potassium channel K2P9.1/TASK-3 (IC50 = 0.035 µM).{53780} It is selective for K2P9.1/TASK-3 over K2P2.1/TREK1 and the voltage-gated potassium channel subtype Kv1.5 (IC50s = ~5 and >10 µM, respectively), as well as a panel of more than 100 receptors, ion channels, and enzymes at 10 µM but does inhibit K2P3.1/TASK-1 (IC50 = 0.3 µM). PK-THPP (100 mg/kg, s.c.) increases the time spent awake and decreases the duration of rapid eye movement (REM) and delta sleep in mice.

• Artikelnummer: CAY29473-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29473-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK