Plecanatide (acetate), CAS 1075732-84-1

Formulation: A solid

Formal Name: L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine, cyclic (4→12),(7→15)-bis(disulfide), monoacetate

Purity: ≥98%

Formula Markup: C65H104N18O26S4 • C2H4O2

Formula Weight: 1741,9

Shelf life (days): 1460

CAS Number: 1075732-84-1

Notes: Plecanatide is a peptide agonist of the guanylate cyclase C receptor.{62429} It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67, a marker of cell proliferation, induced by dextran sulfate (DSS; Item No. 23250) in cancer-prone Apc+/Min-FCCC mice.{62430} It suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity when administered at doses of 0.01 and 0.05 mg/kg.{62431} Formulations containing plecanatide have been used in the treatment of chronic idiopathic constipation.

• Artikelnummer: CAY33878-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33878-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK