Plerixafor-d4, CAS 1246819-87-3

Formulation: A solid

Formal Name: 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene-d4

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C28H50D4N8

Formula Weight: 506,8

Shelf life (days): 1460

CAS Number: 1246819-87-3

Notes: Plerixafor-d4 is intended for use as an internal standard for the quantification of plerixafor (Item No. 10011332) by GC- or LC-MS. Plerixafor is a partial antagonist of chemokine receptor 4 (CXCR4) with IC50 values ranging from 0.02 to 0.13 µg/ml for inhibiting calcium flux in peripheral blood mononuclear cells (PBMCs), various types of T cells, and mouse lymphocytic leukemia cells.{42569} It is selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 µg/ml). Plerixafor decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 µg/ml).{16446} It rapidly mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation alone and, with a synergistic effect, when used in combination with G-CSF.{15446} Plerixafor also increases T cell trafficking in mouse blood, spleen, and central nervous system.{16445,16447} Plerixafor (1.25 mg/kg twice per day) decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis.{15450}

• Artikelnummer: CAY26490-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26490-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung