PPTN (hydrochloride), CAS 1992047-65-0

Formulation: A solid

Formal Name: 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid, monohydrochloride

Purity: ≥98%

Formula Markup: C29H24F3NO2 • HCl

Formula Weight: 512

Shelf life (days): 1460

CAS Number: 1992047-65-0

Notes: PPTN is an antagonist of the purinergic P2Y14 receptor.{66094} It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1β and chemokine (C-C motif) ligand 2 (CCL2) secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat satellite glial cells (SGCs).{66095} Trigeminal administration of PPTN (5 and 10 µM) reduces mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) in rats.{66096}

• Artikelnummer: CAY36854-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36854-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe