Prolactin-Releasing Peptide (1-31) (human), CAS 215510-22-8

Formulation: A lyophilized powder

Formal Name: L-seryl-L-arginyl-L-threonyl-L-histidyl-L-arginyl-L-histidyl-L-seryl-L-methionyl-L-α-glutamyl-L-isoleucyl-L-arginyl-L-threonyl-L-prolyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-prolyl-L-alanyl-L-tryptophyl-L-tyrosyl-L-alanyl-L-seryl-L-arginylglycyl-L-isoleucyl-L-arginyl-L-prolyl-L-valylglycyl-L-arginyl-L-phenylalaninamide

Purity: ≥95%

Formula Markup: C160H252N56O42S

Formula Weight: 3664,2

Shelf life (days): 1460

CAS Number: 215510-22-8

Notes: Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.{43061} It is found in the hypothalamus, medulla, and pituitary in rats.{43062} PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively).{43062,43063} It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM).{43062,43063} PrRP (100 nM) increases the release of gonadotropin-releasing hormone (GnRH; Item No. 24762), vasoactive intestinal peptide (VIP; Item No. 24996), and galanin (Item No. 24456) from rat medial basal hypothalamic explants.{43064} It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol.{43064} PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.{43061}

• Artikelnummer: CAY24986
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24986-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK