Propionylpromazine (hydrochloride), CAS 7681-67-6

Formulation: A solid

Formal Name: 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone, monohydrochloride

Purity: ≥93%

Formula Markup: C20H24N2OS • HCl

Formula Weight: 376,9

Shelf life (days): 1460

CAS Number: 7681-67-6

Notes: Propionylpromazine is a promazine neuroleptic and dopamine receptor antagonist.{61016, 61012, 61013} It is an antagonist at the I. scapularis (tick) dopamine 2 receptor (Isdop2) and A. aegypti (mosquito) dopamine 2 receptor (AaDOP2), providing 94 and 85% inhibition, respectively, in a chemical screening assay at 10 µM.{61012, 61013} Propionylpromazine inhibits recombinant T. cruzi trypanothione reductase (IC50 = 357 µM) and is active against T. brucei trypomastigotes (ED50 = 10.1 µM) but not L. donovani amastigotes or T. cruzi trypomastigotes (ED50s = >30 µM) in mouse peritoneal macrophages.{61014} It increases survival of C. elegans in a model of paraquat-induced oxidative stress.{61015} Propionylpromazine reduces stereotypic behavior induced by apomorphine in rats (ED50 = 2.5 mg/kg, s.c.).{61016} Formulations containing propionylpromazine have been used as tranquilizers in veterinary medicine.

• Artikelnummer: CAY31470-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31470-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK