Prosaptide TX14(A) (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-threonyl-D-alanyl-L-leucyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-asparaginyl-L-alanyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-leucyl-L-tyrosine, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C69H110N16O26 • XCF3COOH

Formula Weight: 1579,7

Shelf life (days): 1460

Notes: Prosaptide TX14(A) is a peptide fragment of the neurotrophic factor prosaposin and an agonist of GPR37L1 and GPR37.{57644} It activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s = 5 and 7 nM, respectively) and inhibits forskolin-induced cAMP production in the same cells. Prosaptide TX14(A) (100 nM) protects primary mouse astrocytes from hydrogen peroxide-induced cell death. It reduces allodynia in a variety of rat peripheral pain models, including models of diabetic neuropathy and sciatic nerve hemiligation when administered at a dose of 4 mg/kg, as well as prevents paw allodynia induced by formalin at 1 mg/kg.{57643}

• Artikelnummer: CAY33935-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33935-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK