Protopine (hydrochloride), CAS 6164-47-2

Formulation: A crystalline solid

Formal Name: 4,6,7,14-tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, monohydrochloride

Purity: ≥98%

Formula Markup: C20H19NO5 • HCl

Formula Weight: 389,8

Shelf life (days): 1460

CAS Number: 6164-47-2

Notes: Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities.{41158} It inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607), platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma at a concentration of 100 μM.{41159} Protopine inhibits contraction of isolated rat thoracic aorta induced by norepinephrine (Item No. 16673) and is a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes.{41160,41161} Protopine inhibits the growth of H. pylori with an MIC50 value of 100 μg/ml.{41162} It reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest.{41163} Protopine (0.005 mg/kg) increases latency to first seizure in a mouse model induced by pentylenetetrazole (Item No. 18682).{41164}

• Artikelnummer: CAY23366-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23366-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK