Prunetin, CAS 552-59-0

Formulation: A crystalline solid

Formal Name: 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one

Purity: ≥95%

Formula Markup: C16H12O5

Formula Weight: 284,3

Shelf life (days): 1460

CAS Number: 552-59-0

Notes: Prunetin is an isoflavone that has been found in P. yedoensis and has diverse biological activities.{45706,16840,45707,45708,45709} It is an allosteric inhibitor of hamster liver aldehyde dehydrogenase 2 (ALDH2; IC50 = 0.45 µM) and an antagonist of the progesterone receptor when used at concentrations of 25 and 50 µM.{16840,45707} It has estrogenic activity in MVLN cells when used at concentrations ranging from 1 to 50 µM and inhibits proliferation of MCF-7 breast cancer cells when used at 0.01 to 50 µM.{45708} It decreases LPS-induced increases in nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) levels, NOS2/iNOS expression, and NF-κB activation in RAW 264.7 macrophages when used at concentrations of 50 and 100 µM.{45706} Prunetin (10 mg/kg) prevents LPS-induced increases in serum TNF-α, IL-1β, and IL-6 levels in a mouse model of septic shock. It also inhibits the secretion of matrix metalloproteinase-3 (MMP-3) in isolated rabbit articular chondrocytes and prevents the production of MMP-3 in the knee joint of rats in a model of osteoarthritis following administration of a 50 or 100 µM dose into the knee joint.{45709}

• Artikelnummer: CAY29432-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29432-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK