PSNCBAM-1, CAS 877202-74-9

Formulation: A solid

Formal Name: N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea

Purity: ≥98%

Formula Markup: C22H21ClN4O

Formula Weight: 392,9

Shelf life (days): 1460

CAS Number: 877202-74-9

Notes: PSNCBAM-1 is a cannabinoid 1 (CB1) receptor negative allosteric modulator (NAM).{42910} It is selective for CB1 over CB2 in HEK293 cells expressing the human receptors (IC50s = 74.3 and >10,000 nM, respectively). PSNCBAM-1 inhibits activation of the CB1 receptor induced by (±)-CP 55,940 (Item No. 13241), anandamide (AEA; Item No. 90050), or 2-arachidonoyl glycerol (2-AG; Item No. 62160) in yeast expressing human CB1 (IC50s = 45.2, 37 and 230.3 nM, respectively). It reduces food intake within one hour and decreases body weight in male rats when administered at a dose of 30 mg/kg. PSNCBAM-1 (10 mg/kg) reduces THC-induced increases in tail-flick latency in mice.{65641}

• Artikelnummer: CAY25855-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25855-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK