Pyrantel (pamoate), CAS 22204-24-6

Formulation: A crystalline solid

Formal Name: 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1)

Purity: ≥95%

Formula Markup: C23H16O6 • C11H14N2S

Formula Weight: 594,7

Shelf life (days): 1460

CAS Number: 22204-24-6

Notes: Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).{46323,46324,46325} It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).{46323,46324} In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).{46325} In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.{46326} Formulations containing pyrantel have been used in the treatment of parasitic worm infections.

• Artikelnummer: CAY27368-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27368-5
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK