Formulation: A solid
Formal Name: 1-[(4-chlorophenyl)methyl]-2-(phenylmethyl)-1H-benzimidazole, monohydrochloride, hydrate
Purity: ≥98%
Formula Markup: C21H17ClN2 • HCl [XH2O]
Formula Weight: 369,3
Shelf life (days): 1460
Notes: Q94 is a Gαq signaling-biased antagonist of proteinase-activated receptor 1 (PAR1; IC50 = 916 nM).{57389,57391} It inhibits increases in intracellular calcium mobilization induced by thrombin or a PAR1-activating peptide, but not a PAR2-activating peptide, in HMEC-1 cells when used at concentrations of 1 and 10 μM.{57389} Q94 (5 mg/kg per day) decreases albuminuria in a mouse model of nephropathy induced by doxorubicin (Item No. 15007).{57390}