(R,S)-Anatabine-d4, CAS 1020719-11-2

Formulation: A solid

Formal Name: 1,2,3,6-tetrahydro-2,3′-bipyridine-2′,4′,5′,6′-d4

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C10H8D4N2

Formula Weight: 164,2

Shelf life (days): 1460

CAS Number: 1020719-11-2

Notes: (R,S)-Anatabine-d4 is intended for use as an internal standard for the quantification of (R,S)-anatabine (Item Nos. 11001 / 15132) by GC- or LC-MS. (R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana).{20193} It is an agonist of α4β2 and α6/α3β2β4 subunit-containing nicotinic acetylcholine receptors (nAChRs; EC50s = 6.1 and 3.6 µM, respectively). It is selective for α4β2 and α6/α3β2β4 subunit-containing nAChRs over α3β4 subunit-containing nAChRs or α7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively).{69082} (R,S)-Anatabine stimulates dopamine, but not norepinephrine, release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively). It increases the time spent at the top of the tank in a novel tank test, indicating anxiolytic-like activity, in zebrafish when used at a concentration of 10 mg/L. (R,S)-Anatabine (0.05 mg/ml in the drinking water) decreases disease severity in a mouse model of moderate, but not low or severe, experimental autoimmune thyroiditis induced by immunization with thyroglobulin, complete Freund’s adjuvant (CFA), and M. tuberculosis.{69083} It decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively).{69084} (R,S)-Anatabine has been used as a biomarker of tobacco use.{20195,20196}

• Artikelnummer: CAY37198
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37198-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung