(R,S)-CHPG, CAS 170846-74-9

Formulation: A solid

Formal Name: α-amino-2-chloro-5-hydroxy-benzeneacetic acid

Purity: ≥98%

Formula Markup: C8H8ClNO3

Formula Weight: 201,6

Shelf life (days): 730

CAS Number: 170846-74-9

Notes: (R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 µM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells.{34104} In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.{23341} It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells.{34106} In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.{34105}

• Artikelnummer: CAY21408-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21408-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK