rac-Tolterodine-d14 (tartrate)

Formulation: A solid

Formal Name: 2-[3-[bis[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-1-phenylpropyl]-4-methyl-phenol, 2,3-dihydroxybutanedioate

Purity: ≥99% deuterated forms (d1-d14)

Formula Markup: C22H17D14NO • C4H6O6

Formula Weight: 489,7

Shelf life (days): 1460

Notes: rac-Tolterodine-d14 is intended for use as an internal standard for the quantification of tolterodine (Item No. 15027) by GC- or LC-MS. Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively).{22772} It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine; Item No. 14486) in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively).{39587} Tolterodine inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively).{39586} Formulations containing tolterodine have been used in the treatment of overactive bladder.

• Artikelnummer: CAY33281
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33281-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung