Ralinepag, CAS 1187856-49-0

Formulation: A solid

Formal Name: 2-[[trans-4-[[[[(4-chlorophenyl)phenylamino]carbonyl]oxy]methyl]cyclohexyl]methoxy]-acetic acid

Purity: ≥95%

Formula Markup: C23H26ClNO5

Formula Weight: 431,9

Shelf life (days): 1460

CAS Number: 1187856-49-0

Notes: Ralinepag is a prostaglandin I2 (PGI2) receptor (IP) agonist (Ki = 3 nM).{50853} It is selective for IP over the PGD2 receptor (DP1) and the PGE2 receptor subtypes EP1-4 (Kis = 2,600, 9,600, 611, 143, and 678 nM, respectively, in radioligand binding assays). Ralinepag induces cAMP accumulation in CHO-K1 cells expressing human recombinant IP (EC50 = 8.5 nM). In vivo, ralinepag (30 mg/kg) prevents increases in pulmonary arterial pressure and vessel wall thickness in a rat model of monocrotaline-induced pulmonary arterial hypertension.

• Artikelnummer: CAY30009-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30009-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK