Raxatrigine (hydrochloride), CAS 934240-31-0

Formulation: A crystalline solid

Formal Name: (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C18H19FN2O2 • HCl

Formula Weight: 350,8

Shelf life (days): 1460

CAS Number: 934240-31-0

Notes: Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav; IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells).{38414} Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated state (IC50 = 6.3 µM) compared to the closed/resting state (IC50 = 54 µM). Raxatrigine (30 mg/kg, i.p.) decreases spontaneous pain behavior in an OD1 mouse pain model.

• Artikelnummer: CAY23490-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23490-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK