Rec 15/2615 (hydrochloride), CAS 1782573-48-1

Formulation: A solid

Formal Name: 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]-ethanone, dihydrochloride

Purity: ≥98%

Formula Markup: C26H33N5O5 • 2HCl

Formula Weight: 568,5

Shelf life (days): 1460

CAS Number: 1782573-48-1

Notes: Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).{53296} It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM).{53295} It decreases diastolic blood pressure (ED25 = 183 µg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 µg/kg.{53296,53295}

• Artikelnummer: CAY27677-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27677-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK