Reduced Haloperidol, CAS 34104-67-1

Formulation: A solid

Formal Name: 4-(4-chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidinebutanol

Purity: ≥98%

Formula Markup: C21H25ClFNO2

Formula Weight: 377,9

Shelf life (days): 730

CAS Number: 34104-67-1

Notes: Reduced haloperidol is an active metabolite of haloperidol (Item No. 12014).{45202} It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells.{33465} It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters).{45202} Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.{45203}

• Artikelnummer: CAY28017-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28017-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK