Reparixin, CAS 266359-83-5

Formulation: A crystalline solid

Formal Name: (αR)-α-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide

Purity: ≥95%

Formula Markup: C14H21NO3S

Formula Weight: 283,4

Shelf life (days): 730

CAS Number: 266359-83-5

Notes: Reparixin is an allosteric antagonist of chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 (IC50s = 1 and 100 nM, respectively).{28557} In vivo, reparixin (3, 15, and 30 mg/kg) reduces ischemia and reperfusion-induced hepatic polymorphonuclear leukocyte (PMN) recruitment, hepatic myeloperoxidase (MPO) levels, and serum alanine transaminase (ALT) levels in a rat model of hepatic ischemia. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg.{28553} Reparixin, in combination with docetaxel (Item No. 11637), reduces tumor volume and the number of intratumor cancer stem cells in a SUM159 triple-negative breast cancer (TNBC) mouse xenograft model.{28554}

• Artikelnummer: CAY17350-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17350-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe