Reparixin (L-Lysine salt), CAS 266359-93-7

Reparixin (L-Lysine salt), CAS 266359-93-7
Artikelnummer
CAY21492-5
Verpackungseinheit
5 mg
Hersteller
Cayman Chemical

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Formulation: A crystalline solid

Formal Name: (αR)-α-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide, L-lysine

Purity: ≥95%

Formula Markup: C14H21NO3S • C6H14N2O2

Formula Weight: 429,6

Shelf life (days): 1460

CAS Number: 266359-93-7

Notes: Reparixin is a non-competitive allosteric inhibitor of the activation of CXCR1 and CXCR2 chemokine receptors by IL-8 (IC50s = 1 and 100 nM, respectively).{28557} It blocks a range of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists.{28557} In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks reduces blood pressure by inhibiting hypertension-related mediators, IL-8, 12-lipoxygenase, and endothelin-1.{28553} Reparixin blockade (100 nM) of CXCR1 depletes a cancer stem cell population in human breast cancer cell lines in vitro.{28554}
Mehr Informationen
Artikelnummer CAY21492-5
Hersteller Cayman Chemical
Hersteller Artikelnummer 21492-5
Green Labware Nein
Verpackungseinheit 5 mg
Mengeneinheit STK
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