Rifampicin-d3, CAS 1262052-36-7

Formulation: A solid

Formal Name: 3-[[(4-(methyl-d3)-1-piperazinyl)imino]methyl]-rifamycin

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C43H55D3N4O12

Formula Weight: 826

Shelf life (days): 1460

CAS Number: 1262052-36-7

Notes: Rifampicin-d3 is intended for use as an internal standard for the quantification of rifampicin (Item No. 14423) by GC- or LC-MS. Rifampicin is a rifamycin antibiotic and inhibitor of bacterial RNA polymerase (IC50 = 0.01 μg/ml for the E. coli enzyme).{23992} It inhibits the growth of M. tuberculosis H37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species of Staphylococcus, Streptococcus, Haemophilus, and Neisseria (MICs = 0.009-1.4 μg/ml).{40531,32022} Rifampicin increases survival in a mouse model of tuberculosis infection.{32022} It is also an agonist of the human pregnane X receptor (PXR; EC50 = ~2 μM).{23996} Formulations containing rifampicin have been used in the treatment of tuberculosis and meningococcal carriers.

• Artikelnummer: CAY27848
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27848-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung