Formulation: A solid
Formal Name: N-(dicyclopropylmethyl)-4,5-dihydro-4,5-d2-2-oxazol-4,5-d2-amine
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C10H12D4N2O
Formula Weight: 184,3
Shelf life (days): 1460
CAS Number: 85047-14-9
Notes: Rilmenidine-d4 is intended for use as an internal standard for the quantification of rilmenidine (Item No. 16988) by GC- or LC-MS. Rilmenidine is an antihypertensive agent.{61133} It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.{61134} Rilmenidine (1 µM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.{30143} Formulations containing rilmenidine have been used in the treatment of hypertension.