Riluzole, CAS 1744-22-5

Formulation: A solid

Formal Name: 6-(trifluoromethoxy)-2-benzothiazolamine

Purity: ≥98%

Formula Markup: C8H5F3N2OS

Formula Weight: 234,2

Shelf life (days): 1460

CAS Number: 1744-22-5

Notes: Riluzole is an inhibitor of calcium channels.{51334} It is selective for the voltage-gated calcium channels Cav2.2 and Cav2.1 over Cav1.2 at 30 µM. Riluzole (10 µM) inhibits increases in intracellular calcium levels induced by NMDA (Item No. 14581), L-glutamic acid (Item No. 30377), or veratridine in primary rat cerebellar granule cells.{51335} It reduces glutamate, but not aspartate, release from the left caudate nucleus in cats when used at a concentration of 10 µM.{51336} Riluzole reduces slow wave activity and increases high frequency neuronal activity induced by carotid artery occlusion (CAO) in gerbils in a dose-dependent manner and decreases the CAO-induced infarcted cortex volume in rats when administered at a dose of 8 mg/kg.{51337} Dietary administration of riluzole (44 mg/kg per day) increases survival time and the total distance ran in an SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS).{51333} Formulations containing riluzole have been used in the treatment of ALS.

• Artikelnummer: CAY35833-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35833-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe