Rimonabant, CAS 168273-06-1

Formulation: A crystalline solid

Formal Name: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

Purity: ≥98%

Formula Markup: C22H21Cl3N4O

Formula Weight: 463,8

Shelf life (days): 1460

CAS Number: 168273-06-1

Notes: Rimonabant is a cannabinoid 1 (CB1) receptor antagonist (Ki = 5.6 nM).{3133} It is selective for CB1 over CB2 receptors (Ki = >1,000 nM), as well as a panel of 37 other receptors and channels (IC50s = >1,000 nM). Rimonabant (10 µM) inhibits phytohemagglutinin-induced proliferation of isolated human peripheral blood mononuclear cells (PBMCs).{17167} Intraperitoneal administration of rimonabant prevents decreases in body temperature and increases in tail-flick latency induced by the CB1 and CB2 receptor agonist (+)-WIN 55,212-2 (Item No. 10009023) in mice (ED50s = 0.28 and 1.62 mg/kg, respectively) and oral administration reduces body weight in a mouse model of diet-induced obesity when administered at a dose of 10 mg/kg in the drinking water.{3133,17600} Rimonabant (10 mg/kg) decreases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiety-like activity.{68311} Formulations containing rimonabant have previously been used in the treatment of obesity.

• Artikelnummer: CAY9000484-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9000484-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK