Rimonabant-d10, CAS 929221-88-5

Formulation: A solid

Formal Name: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl-2,2',3,3',4,4',5,5',6,6'-d10)-1H-pyrazole-3-carboxamide

Purity: ≥99% deuterated forms (d1-d10); ≤1% d0

Formula Markup: C22H11Cl3D10N4O

Formula Weight: 473,8

Shelf life (days): 1460

CAS Number: 929221-88-5

Notes: Rimonabant-d10 is intended for use as an internal standard for the quantification of rimonabant (Item No. 9000484) by GC- or LC-MS. Rimonabant is a cannabinoid 1 (CB1) receptor antagonist (Ki = 5.6 nM).{3133} It is selective for CB1 over CB2 receptors (Ki = >1,000 nM), as well as a panel of 37 other receptors and channels (IC50s = >1,000 nM). Rimonabant (10 µM) inhibits phytohemagglutinin-induced proliferation of isolated human peripheral blood mononuclear cells (PBMCs).{17167} Intraperitoneal administration of rimonabant prevents decreases in body temperature and increases in tail-flick latency induced by the CB1 and CB2 receptor agonist (+)-WIN 55,212-2 (Item No. 10009023) in mice (ED50s = 0.28 and 1.62 mg/kg, respectively) and oral administration reduces body weight in a mouse model of diet-induced obesity when administered at a dose of 10 mg/kg in the drinking water.{3133,17600} Rimonabant (10 mg/kg) decreases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiety-like activity.{68311} Formulations containing rimonabant have previously been used in the treatment of obesity.

• Artikelnummer: CAY9001821-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001821-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung