RJR 2429 (hydrochloride), CAS 1021418-53-0

Formulation: A solid

Formal Name: 2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane, dihydrochloride

Purity: ≥98%

Formula Markup: C12H16N2 • 2HCl

Formula Weight: 261,2

Shelf life (days): 1460

CAS Number: 1021418-53-0

Notes: RJR 2429 is a nicotinic acetylcholine receptor (AChR) agonist.{49443} It is selective for α4β2 or α7 subunit-containing nicotinic AChRs (Kis = 0.7 and 10.9 nM in isolated rat cortex and isolated rat hippocampus, respectively) over α1βɣδ subunit-containing nicotinic AChRs (EC50 = 1,000 nM in PC12 cells). RJR 2429 induces dopamine release from isolated rat striatal synaptosomes (EC50 = 2.4 nM) and increases nicotine-induced elevations in epinephrine and norepinephrine levels in isolated rat adrenal gland when used at a concentration of 100 µM.{49444},{49446} It inhibits nicotine-induced ion flux in isolated rat thalamic synaptosomes (IC50 = 154 nM).{49444}

• Artikelnummer: CAY29745-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29745-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK