RN-1734, CAS 946387-07-1

Formulation: An oil

Formal Name: 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C14H22Cl2N2O2S

Formula Weight: 353,3

Shelf life (days): 730

CAS Number: 946387-07-1

Notes: RN-1734 is a transient receptor potential vanilloid 4 (TRPV4) antagonist, blocking calcium influx induced by the TRPV4 agonist 4α-phorbol 12,13-didecanoate (Item No. 20446) with IC50 values of 2.3, 5.9, and 3.2 µM for human, mouse, and rat TRPV4, respectively.{41579} It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = >100, >30, and >30 µM, respectively). RN-1734 (10 µM) reduces GSK1016790A-induced increases in glycine-activated current (IGly) from 34.5 to 0.97% in mouse hippocampal neurons in vitro.{41580} It blocks arteriolar dilation induced by GSK1016790A (Item No. 17289) and increases myogenic tone in rat cremaster arterioles ex vivo when used at a concentration of 30 µM.{41581} RN-1734 (1 mg/kg, i.p.) reduces edema and MAPK signaling induced by traumatic brain injury in rats.{41582} It also inhibits breakdown of the blood-retinal barrier in streptozotocin-induced diabetic rats when administered at a dose of 100 µM.{41583}

• Artikelnummer: CAY24205-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24205-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK