Ro 04-6790 (hydrochloride hydrate)

Formulation: A solid

Formal Name: 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide, dihydrochloride hydrate

Purity: ≥98%

Formula Markup: C12H16N6O2S • 2HCl [XH2O]

Formula Weight: 381,3

Shelf life (days): 1460

Notes: Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 44.7 nM).{62224} It is selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75). In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats.{62223} Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.{62225}

• Artikelnummer: CAY34476-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34476-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK