Formulation: A crystalline solid
Formal Name: 5-[[4,5-dimethoxy-2-(1-methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
Purity: ≥98%
Formula Markup: C16H22N4O2
Formula Weight: 302,4
Shelf life (days): 1460
CAS Number: 1026582-88-6
Notes: RO-3 is a dual antagonist of the purinergic receptor subtypes P2X3 and P2X2/3 (IC50s = 0.1 and 1.26 μM, respectively).{48818} It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 receptors (IC50s = >10 μM for all) but is an antagonist of ML1-type melatonin receptors (IC50 = 0.398 μM).