Formulation: A crystalline solid
Formal Name: [6-chloro-1-[2-(dimethylamino)ethyl]-1H-indol-3-yl]spiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl-methanone
Purity: ≥98%
Formula Markup: C25H28ClN3O2
Formula Weight: 438
Shelf life (days): 1460
CAS Number: 920022-47-5
Notes: RO5028442 is a brain-penetrant antagonist of vasopressin V1a receptors (Kis = 1 and 39 nM for the human and mouse receptors, respectively).{58074} It is greater than 30,000-fold selective for V1 over V2 receptors, as well as over a panel of 120 receptors, ion channels, and enzymes at 3 µM.