RO5166017, CAS 1048346-74-2

Formulation: A crystalline solid

Formal Name: (4S)-2-amino-N-ethyl-4,5-dihydro-N-phenyl-4-oxazolemethanamine

Purity: ≥95%

Formula Markup: C12H17N3O

Formula Weight: 219,3

Shelf life (days): 1460

CAS Number: 1048346-74-2

Notes: RO5166017 is an agonist of trace amine-associated receptor 1 (TAAR1).{52944} It binds to TAAR1 (Kis = 31, 24, 1.9, and 2.7 nM in HEK293 cells expressing the recombinant human, cynomolgus monkey, mouse, or rat receptor, respectively) and is greater than 15-fold selective for TAAR1 over a panel of 123 receptors, ion channels, and transporters at 10 µM. RO5166017 induces cAMP production in HEK293 cells expressing the recombinant human, cynomolgus monkey, mouse, or rat TAAR1 (EC50s = 55, 97, 3.3, and 14 nM, respectively). It reduces the frequency of neuronal firing in mouse ventral tegmental area (VTA) and dorsal raphe nucleus (DRN) slices (IC50s = 1.73 and 2.99 nM, respectively), which endogenously express high levels of dopaminergic and serotonergic neurons, respectively. RO5166017 (0.3 mg/kg) inhibits stress-induced hyperthermia, indicating anxiolytic-like activity, as well as reduces cocaine-induced hyperlocomotion, in mice. It also impairs expression, but not reconsolidation, of cocaine-induced place preference in rats.{52945}

• Artikelnummer: CAY32972-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32972-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK