Ropinirole (hydrochloride), CAS 91374-20-8

Formulation: A solid

Formal Name: 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one, monohydrochloride

Purity: ≥98%

Formula Markup: C16H24N2O • HCl

Formula Weight: 296,8

Shelf life (days): 1460

CAS Number: 91374-20-8

Notes: Ropinirole is a potent dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay).{38497} It is selective for D2 over D1 dopamine receptors (Ki = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson's disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson's disease motor dysfunction.

• Artikelnummer: CAY23871-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23871-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK