RS 102221 (hydrochloride), CAS 187397-18-8

Formulation: A solid

Formal Name: N-[5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)-benzenesulfonamide, monohydrochloride

Purity: ≥98%

Formula Markup: C27H31F3N4O7S • HCl

Formula Weight: 649,1

Shelf life (days): 1460

CAS Number: 187397-18-8

Notes: RS 102221 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2C.{53989} It binds to 5-HT2C receptors (Ki = 3.8 nM for the recombinant human receptor) and is selective for 5-HT2C receptors over 5-HT2A and 5-HT2B receptors (Kis = 1,122.02 and 812.83 nM, respectively), as well as a panel of additional neurotransmitter receptors and ion channels (Kis = ≥316.23 nM for all). RS 102221 inhibits 5-HT-induced increases in the extracellular media acidification rate of CHO-K1 cells expressing human 5-HT2C receptors (pA2 = 8.1). It increases food intake and weight gain in rats when administered at a dose of 2 mg/kg. RS 102221 (2 mg/kg) increases the time spent in the light compartment in the light-dark exploration test in mice and reduces prepulse inhibition of the startle reflex when administered at a dose of 1 mg/kg.{53990}

• Artikelnummer: CAY31543-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31543-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK