RS 17053 (hydrochloride), CAS 169505-93-5

Formulation: A solid

Formal Name: 5-chloro-N-[2-[2-(cyclopropylmethoxy)phenoxy]ethyl]-α,α-dimethyl-1H-indole-3-ethanamine, monohydrochloride

Purity: ≥98%

Formula Markup: C24H29ClN2O2 • HCl

Formula Weight: 449,4

Shelf life (days): 1460

CAS Number: 169505-93-5

Notes: RS 17053 is an α1A-adrenergic receptor (α1A-AR) antagonist.{18268} It selectively binds to the α1A-AR (Ki = 2.5 nM) over α1B- and α1D-ARs (Kis = 50 and 79 nM, respectively). RS 17053 inhibits norepinephrine-induced contractions in isolated rat kidney and mesenteric arteries (pA2s = 9.8 and 9.9, respectively), tissues that endogenously express high levels of α1A-AR, and, to a lesser extent, in isolated rat aortic rings, which highly express α1D-ARs, and human lower urinary tract tissue (pA2s = 7.7 and 7.3, respectively).{62039} It also inhibits phenylephrine-induced increases in mean arterial pressure (MAP) in normotensive and spontaneously hypertensive rats (ED50s = 528 and 533 µg/kg, respectively).{62040}

• Artikelnummer: CAY33548-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33548-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK