Rupatadine (fumarate), CAS 182349-12-8

Formulation: A crystalline solid

Formal Name: 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, (2E)-2-butenedioate

Purity: ≥98%

Formula Markup: C26H26ClN3 • C4H4O4

Formula Weight: 532

Shelf life (days): 1460

CAS Number: 182349-12-8

Notes: Rupatadine is an antagonist of histamine H1 and platelet-activating factor (PAF) receptors.{46659} It binds to rabbit platelet membranes and guinea pig cerebellum membranes with apparent Ki values of 0.55 and 0.1 µM, respectively, in radioligand binding assays. It inhibits contraction of isolated guinea pig ileum induced by histamine (pA2 = 9.29) and platelet aggregation induced by PAF in washed rabbit platelets (pA2 = 6.68). Rupatadine prevents histamine- or PAF-induced hypotension in rats (ID50s = 1.4 and 0.44 mg/kg, respectively) and reverses histamine- or PAF-induced bronchoconstriction in guinea pigs (ID50s = 113 and 9.6 mg/kg, respectively). It does not reduce locomotor activity or potentiate sleep induced by barbiturates in mice, indicating a lack of sedative effects.

• Artikelnummer: CAY29478-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29478-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK