S26948, CAS 353280-43-0

S26948, CAS 353280-43-0
Artikelnummer
CAY29722-5
Verpackungseinheit
5 mg
Hersteller
Cayman Chemical

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Formulation: A solid

Formal Name: 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid, 1,3-dimethyl ester

Purity: ≥98%

Formula Markup: C28H25NO7S

Formula Weight: 519,6

Shelf life (days): 1460

CAS Number: 353280-43-0

Notes: S26948 is a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 8.83 nM in a transactivation assay).{20850} It is selective for PPARγ over PPARα, PPARβ/δ, and retinoid X receptor α (RXRα) at 10 μM. S26948 (30 mg/kg per day) decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes. It decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet when administered at a dose of 30 mg/kg.
Mehr Informationen
Artikelnummer CAY29722-5
Hersteller Cayman Chemical
Hersteller Artikelnummer 29722-5
Green Labware Nein
Verpackungseinheit 5 mg
Mengeneinheit STK
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