Safinamide (mesylate), CAS 202825-46-5

Formulation: A crystalline solid

Formal Name: 2S-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide, monomethanesulfonate

Purity: ≥98%

Formula Markup: C17H19FN2O2 • CH3SO3H

Formula Weight: 398,4

Shelf life (days): 1460

CAS Number: 202825-46-5

Notes: Safinamide is an inhibitor of monoamine oxidase B (MAO-B; IC50 = ~0.1 μM).{33890} It is selective for MAO-B over MAO-A (IC50 = >10 μM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 μM, respectively).{46371} Safinamide inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons in a concentration-dependent manner. It inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 μM). Safinamide inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline (Item No. 11727), picrotoxin (Item No. 20771), 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively).{46372} Formulations containing safinamide have been used as adjunctive treatments to levodopa and carbidopa in the treatment of “off” episodes associated with Parkinson’s disease.

• Artikelnummer: CAY21546-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21546-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK