SAR7334 (hydrochloride), CAS 1333207-63-8

Formulation: A crystalline solid

Formal Name: 4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-benzonitrile, dihydrochloride

Purity: ≥98%

Formula Markup: C21H22ClN3O • 2HCl

Formula Weight: 440,8

Shelf life (days): 1460

CAS Number: 1333207-63-8

Notes: SAR7334 is a transient receptor potential canonical 6 (TRPC6) channel blocker (IC50 = 7.9 nM).{47571} It is selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively). SAR7334 (0.2-1 μM) blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung. It also inhibits oxidative stress-induced apoptosis and increases autophagic flux in primary mouse renal proximal tubule cells.{47572}

• Artikelnummer: CAY28292-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28292-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK