Sarpogrelate-d3 (hydrochloride), CAS 2934185-00-7

Formulation: A solid

Formal Name: butanedioic acid, 1-[2-(dimethylamino)-1-[[2-[2-[3-(methoxy-d3)phenyl]ethyl]phenoxy]methyl]ethyl] ester, monohydrochloride

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C24H28D3NO6 • HCl

Formula Weight: 469

Shelf life (days): 1460

CAS Number: 2934185-00-7

Notes: Sarpogrelate-d3 is intended for use as an internal standard for the quantification of sarpogrelate (hydrochloride) (Item No. 24194) by GC- or LC-MS. Sarpogrelate is a selective antagonist of the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 3.02, 269, and 37.2 nM, respectively, for human recombinant receptors expressed in CHO-K1 cells).{39654} It is selective for 5-HT2 (Ki = 70.8 nM) over 5-HT1 (Ki = >26,000 nM), α1-, α2-, and β-adrenergic (Kis = 640-123,800 nM), and muscarinic receptors (Ki = >40,000 nM).{39658} In vitro, it inhibits aggregation of rat whole blood induced by collagen, 5-HT (Item No. 14332) with collagen, and 5-HT with ADP (Item No. 16778; IC50s = 57.7, 0.56, and 22.7 μM, respectively).{39655} In vivo, it inhibits leukocyte-endothelial interactions in the femoral artery induced by a high-fat high-fructose diet (HFFD) in mice when administered at a dose of 5 mg/kg per day.{39656} Sarpogrelate (5 mg/kg per day) decreases ventricular hypertrophy and infarct size in a rat model of myocardial infarction.{39657}

• Artikelnummer: CAY33472-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33472-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung