SB-243213 (hydrochloride), CAS 1780372-25-9

Formulation: A solid

Formal Name: 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-indole-1-carboxamide, dihydrochloride

Purity: ≥98%

Formula Markup: C22H19F3N4O2 • 2HCl

Formula Weight: 501,3

Shelf life (days): 1460

CAS Number: 1780372-25-9

Notes: SB-243213 is an inverse agonist of the serotonin (5-HT) receptor subtype 5-HT2C.{62633} It is selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (Kis = 0.001, 0.158, and 0.1 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 (IC50s = >100, 23, >100, >100, and >100 µM, respectively). SB-243213 reduces the basal activity of 5-HT2C in HEK293 cells expressing the human 5-HT2C receptor (pKB = 9.5). It reverses mCPP-induced hypolocomotion in rats (ID50 = 0.7 mg/kg). SB-243213 (0.2-5 mg/kg) has anxiolytic-like activity in the social interaction test in rats.

• Artikelnummer: CAY36217-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36217-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe