SB-332235, CAS 276702-15-9

Formulation: A solid

Formal Name: 6-chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxy-benzenesulfonamide

Purity: ≥95%

Formula Markup: C13H10Cl3N3O4S

Formula Weight: 410,7

Shelf life (days): 1460

CAS Number: 276702-15-9

Notes: SB-332235 is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2; IC50 = 9.3 nM in CHO cell membranes expressing the recombinant human receptor).{59731} It is selective for CXCR2 over CXCR1 (IC50 = 9,633 nM). SB-332235 (10 ng/ml) inhibits migration of isolated human peripheral blood monocytes induced by chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL5, or CXCL8 by 92, 73, and 50%, respectively.{59732} It decreases cigarette smoke-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration when administered at a dose of 1 mg/kg.{59733} SB-332235 (1 mg/kg) reduces increases in neuronal levels of 4-hydroxy nonenal (4-HNE; Item No. 32100) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in a rat model of Alzheimer's disease.{59734}

• Artikelnummer: CAY32869-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32869-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK