SB-399885 (hydrochloride), CAS 402713-81-9

Formulation: A crystalline solid

Formal Name: N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide, monohydrochloride

Purity: ≥98%

Formula Markup: C18H21Cl2N3O4S • HCl

Formula Weight: 482,8

Shelf life (days): 1460

CAS Number: 402713-81-9

Notes: SB-399885 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.72 nM).{61175} It is greater than 200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM. SB-399885 inhibits 5-HT-induced cAMP accumulation in HeLa cells expressing recombinant human 5-HT6 receptors (pA2 = 7.85). In vivo, SB-399885 increases the seizure threshold in a rat model of seizures induced by maximal electroshock (MES). It reduces escape latency in the Morris water maze in aged rats and reverses scopolamine-induced impairments in the novel object recognition task in adult rats when administered at a dose of 10 mg/kg. SB-399885 (10 mg/kg) decreases immobility time in the forced swim and tail suspension tests in mice.{61176} It also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.

• Artikelnummer: CAY32817-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32817-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK