Senicapoc, CAS 289656-45-7

Formulation: A solid

Formal Name: 4-fluoro-α-(4-fluorophenyl)-α-phenyl-benzeneacetamide

Purity: ≥98%

Formula Markup: C20H15F2NO

Formula Weight: 323,3

Shelf life (days): 1460

CAS Number: 289656-45-7

Notes: Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels.{46700,46701} It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (Item No. 11016; IC50s = 11 and 30 nM, respectively).{46700} Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 / 11932) when used at a concentration of 1 μM.{46702} Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.{46701}

• Artikelnummer: CAY29679-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29679-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK