Setipiprant, CAS 866460-33-5

Formulation: A solid

Formal Name: 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid

Purity: ≥98%

Formula Markup: C24H19FN2O3

Formula Weight: 402,4

Shelf life (days): 1460

CAS Number: 866460-33-5

Notes: Setipiprant is an orally bioavailable antagonist of the prostaglandin D2 (PGD2; Item No. 12010) receptor CRTH2/DP2 (IC50 = 6 nM for the human receptor).{42901} It is selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and the prostaglandin E2 (PGE2; Item No. 14010) receptor subtypes EP2 and EP4 in a β-arrestin assay (IC50s = 2,600 and >10,000 nM, respectively). Setipiprant inhibits PGD2-induced calcium flux in HEK293 cells expressing human CRTH2/DP2 (IC50 = 30 nM) and PGD2-induced shape change in human eosinophils (IC50 = 235 nM).

• Artikelnummer: CAY28291-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28291-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK