SGA360, CAS 680611-86-3

Formulation: A crystalline solid

Formal Name: 3-(2,4-dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazole

Purity: ≥98%

Formula Markup: C19H17F3N2O2

Formula Weight: 362,4

Shelf life (days): 1460

CAS Number: 680611-86-3

Notes: SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons.{38254,12907} SGA360 competitively binds to AhR (IC50 = 3 µM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells.{38254} It also reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema. SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis when the high-affinity AhR variant is expressed.{38253}

• Artikelnummer: CAY21986-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21986-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK