Silodosin-d4, CAS 1426173-86-5

Formulation: A solid

Formal Name: (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl-1,1,2,2-d4)amino)propyl)indoline-7-carboxamide

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C25H28D4F3N3O4

Formula Weight: 499,6

Shelf life (days): 1460

CAS Number: 1426173-86-5

Notes: Silodosin-d4 is intended for use as an internal standard for the quantification of silodosin (Item No. 14866) by GC- or LC-MS. Silodosin is an α1A-adrenergic receptor (α1A-AR) antagonist (Ki = 0.036 nM).{25007} It is 583- and 56-fold selective for α1A- over α1B- and α1D-ARs, respectively. Silodosin inhibits phenylephrine-induced contraction of isolated rabbit prostate (pA2 = 10.05) more potently than rabbit or rat aorta (pA2s = 9.36 and 8.13, respectively).{55032} It inhibits norepinephrine-induced contraction of isolated human prostate tissue when used at concentrations ranging from 0.3 to 10 nM.{25007} Silodosin (0.01-1,000 µg/kg) inhibits phenylephrine-induced increases in intraurethral pressure in rats.{25005} Formulations containing silodosin have been used in the treatment of benign prostatic hyperplasia.

• Artikelnummer: CAY30236
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30236-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung