Sipatrigine, CAS 130800-90-7

Formulation: A crystalline solid

Formal Name: 2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine

Purity: ≥98%

Formula Markup: C15H16Cl3N5

Formula Weight: 372,7

Shelf life (days): 1460

CAS Number: 130800-90-7

Notes: Sipatrigine is a neuroprotective agent and derivative of lamotrigine (Item No. 15428).{59788} It inhibits neuronal voltage-gated sodium and calcium channels in a voltage-dependent manner. Sipatrigine reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices (EC50s = 4.5 and 2 µM, respectively).{59789} It inhibits veratrine-induced glutamate and aspartate release in rat cerebral cortex slices (IC50s = ~5 µM for both).{59790} Sipatrigine (30 mg/kg, i.v.) reduces infarct volume in a rat model of focal ischemia induced by middle cerebral artery occlusion (MCAO).{59791}

• Artikelnummer: CAY32963-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32963-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK