SKA-31, CAS 40172-65-4

Formulation: A solid

Formal Name: naphtho[1,2-d]thiazol-2-amine

Purity: ≥95%

Formula Markup: C11H8N2S

Formula Weight: 200,3

Shelf life (days): 1460

CAS Number: 40172-65-4

Notes: SKA-31 is an activator of the small- and intermediate conductance calcium-activated potassium channels KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay).{52233} It also blocks the voltage-gated potassium (Kv) channels Kv1.3, Kv1.5, Kv3.1, and Kv3.2 by 10 to 30% and the voltage-gated sodium (Nav) channels Nav1.2, Nav1.4, and Nav1.5 by 9 to 40% in a panel of 13 ion channels when used at a concentration of 25 µM. SKA-31 increases vasodilation induced by acetylcholine (Item No. 23829) in isolated mouse carotid artery (EC50 = 93 nM) and induces relaxation of isolated rat mesenteric artery rings precontracted with phenylephrine (IC50 = 93 nM).{52233,52234} It decreases blood pressure in normotensive and angiotensin II-induced hypertensive mice when administered at a dose of 30 mg/kg.{52233}

• Artikelnummer: CAY29690-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29690-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK