SKF 83959 (hydrobromide), CAS 67287-95-0

Formulation: A crystalline solid

Formal Name: 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol, monohydrobromide

Purity: ≥98%

Formula Markup: C18H20ClNO2 • HBr

Formula Weight: 398,7

Shelf life (days): 1460

CAS Number: 67287-95-0

Notes: SKF 83959 is a partial agonist at the dopamine D1-like receptors (Kis = 1.18 and 7.56 nM, respectively, for D1 and D5) that is selective over the D2-like receptors (Kis = 920 and 399 nM, respectively, for D2 and D3).{24103,40094} It is protective against oxidative stress in retinal ganglion cells after hydrogen peroxide-induced injury in vitro.{40095} In a rat methylazoxymethanol acetate (MAM) model of schizophrenia, it had positive effects on hippocampal function, determined using electrophysiology, but impaired spatial learning.{40096} SKF 83959 can also act as an allosteric modulator of the sigma-1 (σ1) receptor by enhancing the binding to and delaying the dissociation of the selective σ1-receptor agonist pentazocine.{40097}

• Artikelnummer: CAY22220-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22220-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK